Synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic non-human mammals
US6613957B1 · kind B1 · utility
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44Claims
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Key dates
| Filing date | Sep 1, 1999 |
| Grant date | Sep 2, 2003 |
| Priority date | — |
| Expiry date | Sep 1, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/948
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic non-human animals and erythroid cell lines. It is based on the discovery that two of the five hypersensitivity sites of the &bgr;-globin locus are sufficient to result in high level expression of human &agr;- or &bgr;-globin transgenes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.