Electrochromatographic device for use in enantioselective separation, and enantioselective separation medium for use therein
US6616825B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 23, 2000 |
| Grant date | Sep 9, 2003 |
| Priority date | — |
| Expiry date | Jul 7, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/0035
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An electrochromatographic device is provided for conducting enantioselective separation of enantiomers. The device is comprised of a conduit containing a monolithic enantioselective separation medium, and may be, for example, a capillary tube or a microchannel in a substrate. The enantioselective separation medium is prepared by copolymerization of (a1) an ionizable chiral monomer or (a2) a chiral monomer and an ionizable comonomer, along with (b) a crosslinking comonomer and (c) a polymerization initiator, in (d) a porogenic solvent. Following ionization, the enantioselective separation medium serves as a charge carrier as well as a chiral separation medium, and further acts as an electroosmotic pump to facilitate the flow of a fluid. The invention also provides methods for preparing the enantioselective separation medium and electrochromatographic devices fabricated therewith.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.