Process for producing microparticles

US6616949B2 · kind B2 · utility

Assignee

• JAGOTEC AG · CH

Inventors

• Monica Jonsson · Bara, SE
• Timo Laakso · Campton, GB
• Mats Reslow · Lund, SE

Key dates

• Filing date: Oct 5, 2001
• Grant date: Sep 9, 2003
• Expiry date: Oct 5, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2985
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for producing microparticles containing biologically active substance, in which process an aqueous solution of the said substance is prepared, this solution is mixed with an aqueous solution of PEG such that the substance is concentrated and/or solidified, the substance is optionally washed, the substance is mixed with an organic polymer solution, the composition obtained is mixed, after the admixture of said polymer solution, with an aqueous polymer solution, thereby forming an emulsion of droplets of first mentioned polymer as the internal phase, said droplets are solidified into microparticles, the microparticles are dried and a release-controlling shell is optionally applied to these.