Identification of drug complementary combinatorial libraries
US6617114B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 30, 1998 |
| Grant date | Sep 9, 2003 |
| Priority date | — |
| Expiry date | Apr 30, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/047
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention is directed to the identification of compounds in a compound library which can mediate the biological activity of a target receptor protein, even when the ligands which mediate that activity through binding to that receptor are not already known.The method of the invention includes the following three steps:(1) Screen a first combinatorial library for members binding to the target protein (TP) and hence capable of use as surrogates for the unknown ligand in steps (2) and (3).(2) Screen a second library, for compounds which inhibit the binding of one or more surrogates from step (1) to TP, and, optionally.(3) Determine whether the inhibitory compound mediates the biological activity of the said TP.The first library is composed of peptides, peptoids and/or nucleic acids, and the second is not.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.