Preparation and drug composition of bis-benzyl-isoquinoline class alkaloids

US6617335B1 · kind B1 · utility

Assignee

• Kanghong USA, Inc. · US

Inventors

• Fengpeng Wang · Chengdu, CN
• Li Shan Wang · Beijing, CN
• Jinsong Yang · Shanghai, CN
• Donglin Chen · Chengdu, CN
• Xixian Jian · Sichuan, CN

Key dates

• Filing date: May 2, 2002
• Grant date: Sep 9, 2003
• Expiry date: May 2, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to the preparation of bis-isoquinoline derivatives of general formula (I) and salts thereof, which possesses multi-drug resistance (MDR) reversal activities. Drug compositions and formulations comprising bis-isoquinoline derivatives of general formula (I) and salts thereof are provided for use as sensitivity enhancers in cancer chemotherapy. Methods for inhibiting MDR by treatment with bis-isoquinoline derivatives are also provided.