Patent · US Expired

Preparation of optically active &agr;-hydroxyethers

US6617475B2 · kind B2 · utility

8Cited by

4References

18Claims

0Family size

Assignee

SOLVIAS AG · CH

Inventors

Martin Studer · Basel, CH
Stephan Burkhardt · Gelterkinden, CH

Key dates

Filing date	Sep 4, 2002
Grant date	Sep 9, 2003
Priority date	—
Expiry date	Sep 4, 2022

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2601/14
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Optically active &agr;-hydroxyethers are prepared from prochiral &agr;-ketoethers by heterogeneous hydrogenation using platinum catalysts in the presence of a chiral nitrogen base in high chemical and optical yields, since this type of hydrogenation selectively hydrogenates only one diastereomer virtually to completion. The yields may be substantially increased by adding a solid, strong base which has a racemizing effect on the non-hydrogenatable diasteromer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.