Chrono delivery formulations and method of use thereof
US6620439B1 · kind B1 · utility
Inventor
Key dates
| Filing date | Oct 3, 2000 |
| Grant date | Sep 16, 2003 |
| Priority date | — |
| Expiry date | Oct 3, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5026
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A dosage formulation for once daily administration prior to sleeping is described that provides an initial delay in pharmaceutical release followed by controlled release of the pharmaceutical. There is also provided a method for preparing a time specific delayed, controlled release formulation of dosage, which method includes coating a single pellet with at least one dosage layer, which is coated by at least one seal coat and at least one outer rate controlling layer of a water soluble polymer coat. The dosage formulation of this invention provides substantially a drug free interval of about 0 to 5 hours followed by a drug delivery interval at a rate permitting bioavailability thereof for up to about 24 hours following oral administration. A method of using the formulations of the present invention for the treatment of early morning pathologies is also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.