Mammalian transformation complex comprising a lipid carrier and DNA encoding CFTR
US6620795B1 · kind B1 · utility
0Cited by
18References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 14, 1999 |
| Grant date | Sep 16, 2003 |
| Priority date | — |
| Expiry date | Dec 14, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions for producing a mammal capable of expressing an exogenously supplied gene in cells of the airway are disclosed. Lipid carrier-nucleic acid complexes or nucleic acid abre are prepared then delivered via aerosol or systemically to the lung abre or lung plus extrapulmonary tissues. The invention provides a direct method for transforming pulmonary cells as a means for treating the manifestations of CF in the lung and involved extrapulmonary tissues.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.