Lactam metalloprotease inhibitors

US6620823B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Pharma Company · US

Inventors

• Thomas P. Maduskuie, Jr. · Wilmington, US
• Jingwu Duan · Yardley, US
• Stephen E. Mercer · Wilmington, US

Key dates

• Filing date: Jul 10, 2001
• Grant date: Sep 16, 2003
• Expiry date: Jul 10, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present application describes novel lactams and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 4-8 membered cyclic amide comprising 0-3 additional heteroatoms selected from N, O, and S, which are useful as metalloprotease inhibitors.