Process for producing stereoisomer of pyrrolidine derivative
US6620945B2 · kind B2 · utility
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Key dates
| Filing date | May 8, 2002 |
| Grant date | Sep 16, 2003 |
| Priority date | — |
| Expiry date | May 8, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a process for producing optically active 3-hydroxy-4-methoxypyrrolidine, which is an intermediate for synthesizing a quinuclidine derivative useful as a squalene synthetase inhibitor, a salt thereof, or a hydrate thereof by subjecting a pyrrolidine derivative represented by the following formula (1-4): wherein R3a and R3b are different and each of R3a and R3b represents a hydrogen atom or a methyl group, to optical division purification by using an optically active dibenzoyltartaric acid derivative or the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.