Methods and compositions for inhibition of membrane fusion-associated events including RSV transmission
US6623741B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 29, 2000 |
| Grant date | Sep 23, 2003 |
| Priority date | — |
| Expiry date | Feb 29, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/18522
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention are derived from regions of viral fusion proteins referred to as HR1 and HR2. In particular, the invention relates to peptides referred to herein as DP107 and DP178 which comprise amino acid sequences corresponding to sequences found in the HR1 and HR2 regions, respectively of the HIV-1LAI gp41 protein. The invention further relates to “DP107-like” and “DP178-like” peptides that are derived from HR1 and HR2 regions, respectively, of other proteins, including DP107-like and DP178-like peptides derived from the HR1 and HR2 regions of the F1 subunit of the respiratory syncytial virus fusion protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.