I-flice, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis
US6623938B2 · kind B2 · utility
3Cited by
0References
20Claims
0Family size
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Key dates
| Filing date | Jan 21, 1998 |
| Grant date | Sep 23, 2003 |
| Priority date | — |
| Expiry date | Jun 2, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of TNFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.