Cellular matrix

US6623963B1 · kind B1 · utility

Assignees

• Verigen AG · US
• Peter Karl Muller · DE
• Peter Behrens · DE
• Jurgen Rohwedel · DE
• Martin Russlies · DE

Inventors

• Peter Karl Müller · Lübeck, DE
• Peter Behrens · Wulfen, DE
• Bruno Giannetti · Bonn, DE
• Jurgen Rohwedel · Lübeck, DE
• Martin Russlies · Lübeck, DE

Key dates

• Filing date: Dec 20, 1999
• Grant date: Sep 23, 2003
• Expiry date: Dec 20, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/06
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A biocompatible, resorbable Type II collagen-based matrix is reconstituted from solubilized animal cartilage tissue and used in the culture and growth of cells, such as chondrocyte cells. The matrix is produced by isolating cartilage tissue, solubilizing and reconstituting the cartilage to form a fleece-like material, pressing the fleece-like material to form a sheet-like article, and sterilizing the article. An implantable article for cartilage repair includes chondrocyte cells retained on the matrix.