Exo1 and Exo2, exocytotic proteins
US6623980B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 23, 1999 |
| Grant date | Sep 23, 2003 |
| Priority date | — |
| Expiry date | Feb 23, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/4703
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is directed to novel exocytotic polypeptides, such as Exo1 and Exo2 polypeptides and related molecules, which have an inhibitory effect on exocytosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are method for identifying novel compositions which mediate exocytotic polypeptide bioactivity, and the use of such compositions in diagnosis and treatment of disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.