Method of production and method of separation of 2,4′-dipyridyl derivatives and methods of production of benzoxazepine derivatives and salts thereof
US6624308B2 · kind B2 · utility
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Key dates
| Filing date | Jun 9, 2000 |
| Grant date | Sep 23, 2003 |
| Priority date | — |
| Expiry date | Jun 9, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of production of 2,4′-dipyridyl derivatives by a cross coupling reaction of a 2-halopyridine derivative and a 4-halopyridine using a nickel complex catalyst and a method of separation of a 2,4′-dipyridyl derivative from a mixture of dipyridyl isomers containing a 2,2′-dipyridyl derivative, 2,4′-dipyridyl derivative, and 4,4′-dipyridyl by using a dilute aqueous copper sulfate solution to insolubilize and remove the 2,2′-dipyridyl derivative and 4,4′-dipyridyl are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.