Method and solid phase calibration sample for calibration of analytical instructions
US6627444B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 7, 2000 |
| Grant date | Sep 30, 2003 |
| Priority date | — |
| Expiry date | Aug 9, 2021 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/25875
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and a solid phase calibrant are provided suitable for use by untrained personnel to calibrate an analytical instrument under field conditions away from a laboratory. Filter discs or other suitable substrates are impregnated, by the process of adsorption, with solutions of known concentrations of analytes and chromatographic phase materials, such as polymers, in suitable solvents. The substrate material is selected to be chemically inert and to not negatively interact with the analytes, the calibration process, or the analytical instrumentation. The polymers cause the analyte to adhere to the substrate until the solution is desorbed by heating, so that the impregnated substrates form stable calibration solutions in solid phase which can be easily and reliably stored, transported, and used by operators with minimal training. The substrate is preferably contained in a card holder which can be easily inserted into and preferably mate with an inlet for the analytical instrument. Within the instrument, the solid phase calibrant is desorbed by heating the substrate to release a standardized amount of analyte calibrant into the instrument. The calibration technique is particularly…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.