Method for selecting functional deoxyribonucleotide derivatives
US6627456B1 · kind B1 · utility
10Cited by
5References
4Claims
0Family size
Inventor
Key dates
| Filing date | Oct 12, 1999 |
| Grant date | Sep 30, 2003 |
| Priority date | — |
| Expiry date | Oct 12, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/143333
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Improvements are disclosed for in vitro selection methods that yield ligands and catalysts through partitioning libraries of oligonucleotides. These improvements all increase the diversity and amount of fuctionality available to the oligonucleotides, by incorporating into the oligonucleotide libraries non-standard nucleobase analogs and/or functionalized standard nucleobases, and/or incorporating into the selection mixture organic cofactors that deliver functional groups by binding non-covalently to oligonucleotides in the library.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.