Methods and compositions for in vivo gene therapy

US6627615B1 · kind B1 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Robert James Debs · Mill Valley, US
• Ning Zhu · 安丰镇, CN

Key dates

• Filing date: Aug 11, 1998
• Grant date: Sep 30, 2003
• Expiry date: Aug 11, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K39/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel methods and compositions are provided for introducing a gene capable of modulating the genotype and phenotype into two or more tissues following systemic administration. The gene can be introduced into a mammalian host by way of an expression vector either as naked DNA or associated with lipid carriers, particularly cationic lipid carriers. Multiple individual tisssues can be transfected using naked DNA. Using a DNA: lipid carrier complex. multiple tissues and cell types can be transfected. The techniques and compositions find use in the palliation or treatment of any of a variety of genetic-based disorders.