Intravascular delivery of non-viral nucleic acid
US6627616B2 · kind B2 · utility
14Cited by
4References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 23, 1999 |
| Grant date | Sep 30, 2003 |
| Priority date | — |
| Expiry date | Nov 23, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then the polynucleotide is inserted into a mammalian vessel such as a tail vein or artery. Prior to insertion, subsequent to insertion, or concurrent with insertion the permeability of the vessel is increased thereby the genetic material is delivered to the parenchymal cell altering endogenous properties of the cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.