Materials and methods for intracellular delivery of biologically active molecules

US6627618B2 · kind B2 · utility

Assignee

• University of Florida Research Foundation, INC. · US

Inventors

• Volkmar Weissig · Glendale, US
• Jeffrey Hughes · Tynong, AU
• Jurgen Lasch · Bodenwerder, DE
• Thomas Rowe · Roswell, US

Key dates

• Filing date: Jan 5, 2001
• Grant date: Sep 30, 2003
• Expiry date: Jan 10, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/92
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The subject invention finds utility in the area of gene therapy of diseases. More specifically, the invention concerns the making of a novel non-viral vector which can bind to desired DNA to form a combination useful to transfect diseased mitochondria of human or animal cells. The non-viral vector comprises a dequalinium salt subjected to standard liposome production procedures to obtain the vector named DQAsomes.