6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
US6627633B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jan 28, 2000 |
| Grant date | Sep 30, 2003 |
| Priority date | — |
| Expiry date | Jan 28, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The compounds of the present invention are 2,6,9-trisubstituted purine inhibitors of cyclin/cdk complexes. The compounds also are potent inhibitors of human cellular proliferation. As such, the compounds constitute pharmaceutical compositions with a pharmaceutically acceptable carrier. Such compounds are useful in inhibiting cellular proliferation in a mammal by administering to such mammal an effective amount of the compound. An example is represented by the following chemical structure: wherein:X=N;R2=phenyl;substituted phenyl;1-naphthyl;2-naphthyl;heterocycles; orsubstituted heterocycle;Y=H;OR1;NHR1;NHC(O)R3;NHSO2R3;NHC(O)NHR3;NHC(O)R5; orNHC(O)OR6;and R1, R3, and R4 are defined herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.