Bicyclic heterocycles, pharmaceutical compositions containing them, their use, and processes for preparing them

US6627634B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Frank Himmelsbach · Mittelbiberach, DE
• Elke Langkopf · Biberach an der Riß, DE
• Birgit Jung · Laupheim, DE
• Stefan Blech · Warthausen, DE
• Flavio Solca · Wien, AT

Key dates

• Filing date: Mar 23, 2001
• Grant date: Sep 30, 2003
• Expiry date: Mar 23, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Bicyclic heterocycles of general formula wherein:Ra to Rd, A to C and X are as defined herein, the tautomers, the stereoisomers and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for treating diseases, particularly tumoral diseases, diseases of the lungs and respiratory tract, and the preparation thereof.