Patent · US Expired

Receptor tyrosine kinase with a discoidin-type binding domain

US6627733B2 · kind B2 · utility

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2References
2Claims
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Inventors

Key dates

Filing dateAug 26, 1998
Grant dateSep 30, 2003
Priority date—
Expiry dateAug 26, 2018

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61K39/00
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

A breast carcinoma tyrosine phosphoprotein, DDR (Discoidin Domain Receptor), that defines a novel class of receptor tyrosine kinases is presented. The DDR cDNA predicts a polypeptide C-terminal tyrosine kinase domain and an N-terminal domain similar to the Dictyostelium discoideum lectin discoidin I. These domains are connected by an extraordinary hydrophilic proline/glycine-rich domain, which is interrupted by a predicted transmembrane sequence. This extended proline/glycine-rich region suggests an unusual geometry of interaction with ligand or substrates. Discoidin I-type domains may interact with specific cell surface molecules.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.