RGD-analog non-peptidic molecules having anti-adhesive, anti-migration and anti-proliferative effects

US6627769B2 · kind B2 · utility

Assignee

• Provincia Italiana della Congregazione dei Figli dell'Immacolata Concezione-Istituto Dermopatico dell'Immacolata · IT

Inventors

• Antonio Facchiano · Roma, IT
• Francesco Facchiano · Roma, IT
• Ivan Rossi · Casalecchio di Reno, IT
• Rita Casadio · Bologna, IT

Key dates

• Filing date: Feb 20, 2002
• Grant date: Sep 30, 2003
• Expiry date: Feb 20, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel molecules without intramolecular peptidic bonds, able to mimic the RGD peptide, containing ARG-GLY-ASP motif “arginine-glycine-aspartic acid” (that is a potent inhibitor, in vivo and in vitro, of cellular adhesion) In vitro experimentation demonstrated that said molecules are efficient inhibitors of RASMC adhesion, proliferation and migration.