Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US6630457B1 · kind B1 · utility
73Cited by
34References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 18, 1998 |
| Grant date | Oct 7, 2003 |
| Priority date | — |
| Expiry date | Sep 18, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/80
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for chemical modification of hyaluronic acid, formation of amine or aldehyde functionalized hyaluronic acid, and the cross-linking thereof to form hydrogels are provided. Functionalized hyaluronic acid hydrogels of this invention can be polymerized in situ, are biodegradable, and can serve as a tissue adhesive, a tissue separator, a drug delivery system, a matrix for cell cultures, and a temporary scaffold for tissue regeneration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.