Phenyl-substituted 1,4-dihydropyridines

US6630494B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Heinrich Meier · Wuppertal, DE
• Wolfgang Hartwig · Wuppertal, DE
• Bodo Junge · Wuppertal, DE
• Rudolf Schohe-Loop · Wuppertal, DE
• Zhan Gao · Beijing, CN
• Bernard Schmidt · Lindlar, DE
• Maarten de Jonge · Overath, DE
• Teunis Schuurman · Overath, DE

Key dates

• Filing date: Feb 12, 2001
• Grant date: Oct 7, 2003
• Expiry date: Feb 28, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel phenyl-substituted 1,4-dihydropyridines, prepared by reacting halogenophenyl-aldehydes with &bgr;-ketoesters, if appropriate with isolation of the ylidene compounds and enamines. The substances can be employed as active compounds in medicaments, in particular in cerebrally active compositions.