Phosphinic pseudo-peptides that may be used as matrix zinc metalloprotease inhibitors

US6630501B1 · kind B1 · utility

Assignees

• COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES · FR
• Institut National de la Recherche Medicale · FR
• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR

Inventors

• Vincent Dive · Palaiseau, FR
• Philippe Cuniasse · Montrouge, FR
• Marie-Christine Rio · Illkirch-Graffenstaden, FR
• Paul Basset · Strasbourg, FR
• Athanasios Yotakis · Paraskevi, GR
• Fabrice Beau · Massy, FR
• Stamania Vassiliou · Municipality of Nea Smyrni, GR

Key dates

• Filing date: Mar 25, 2002
• Grant date: Oct 7, 2003
• Expiry date: Mar 25, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65583
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to pseudo-peptides according to the formula: whereinR1 is a group inhibiting an amine function, or an amino acid residue or peptide with an inhibited terminal amino function,R2 represents the lateral chain of a natural or non-natural amino acid,R3 represents:1) the lateral chain of a natural amino acid except for Gly and Ala, not substituted or substituted by an aryl group,2) an aralkyl group, or3) an alkyl group comprising at least 3 carbon atoms, andR4 represents a lateral chain of natural or non-natural amino acid.They are useful as matrix zinc metalloprotease inhibitors, particularly in the treatment of cancer.