Single chain antibody against mutant p53
US6630584B1 · kind B1 · utility
9Cited by
1References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 16, 2000 |
| Grant date | Oct 7, 2003 |
| Priority date | — |
| Expiry date | Mar 16, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/622
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
More than 90% of mutations found in the p53 protein produce a conformational change in p53 which results in the exposure of an epitope, which is otherwise hidden in the hydrophobic core of the molecule. A single chain antibody (scFv) which specifically recognizes this common mutant epitope in mutant p53 but not in wild type p53 is disclosed. Also described are a DNA molecule encoding the scFv, pharmaceutical compositions comprising the antibody and methods of treatment using the pharmaceutical compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.