Mutants of streptococcal toxin a and methods of use
US6632441B2 · kind B2 · utility
11Cited by
2References
57Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 12, 1998 |
| Grant date | Oct 14, 2003 |
| Priority date | — |
| Expiry date | Mar 12, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention is directed to mutant SPE-A toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-A toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-A toxin. The mutant SPE-A toxins can form vaccine compositions useful to protect animals against the biological activities of wild type SPE-A toxin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.