Compositions for inhalation

US6632456B1 · kind B1 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Kjell Backstrom · Lund, SE
• Carl Magnus Olof Dahlback · Lund, SE
• Peter Edman · Ulricehamn, SE
• Ann Charlotte Birgit Johansson · Lund, SE

Key dates

• Filing date: Oct 24, 1997
• Grant date: Oct 14, 2003
• Expiry date: Oct 24, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/145
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A pharmaceutical composition including a mixture of active compounds (A) a pharmaceutically active polypeptide, and (B) an enhancer compound which enhances the systemic absorption of the polypeptide in the lower respiratory tract of a patient, the mixture being in the form of a dry powder for inhalation in which at least 50% of the total mass of the active compounds consists of primary particles having a diameter less than or equal to about 10 microns, the primary particles optionally being formed into agglomerates.