Compounds that selectively bind to expanded polyglutamine repeat domains and methods of use thereof
US6632616B2 · kind B2 · utility
5Cited by
4References
6Claims
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Assignee
Inventors
Key dates
| Filing date | Feb 9, 2001 |
| Grant date | Oct 14, 2003 |
| Priority date | — |
| Expiry date | Feb 27, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds that selectively bind to expanded polyglutamine repeats are disclosed. Such compounds are characterized in that they bind to a first polyglutamine peptide consisting of 60 glutamine residues under conditions in which they do not bind to a second polyglutamine peptide consisting of 20 glutamine residues. Conjugates of such compounds, nucleic acids encoding the same, and methods of use thereof are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.