Directing the ratio of B2:B1 avermectins in Streptomyces avermitilis host cells
US6632673B1 · kind B1 · utility
2Cited by
13References
42Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 10, 2000 |
| Grant date | Oct 14, 2003 |
| Priority date | — |
| Expiry date | Sep 5, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/623
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.