Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene
US6632976B1 · kind B1 · utility
114Cited by
7References
54Claims
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Key dates
| Filing date | Mar 2, 1998 |
| Grant date | Oct 14, 2003 |
| Priority date | — |
| Expiry date | Mar 2, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/30
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A chimeric, non-human animal can be produced by a method that entails providing a microcell that contains one or more foreign chromosomes or fragment(s) thereof and then fusing the microcell with a pluripotent cell, thereby introducing the foreign chromosome(s) or fragment(s) into the latter. The pluripotent cell thus obtained can be used to generate a chimeric, non-human animal, the cells, tissues, and/or progeny of which can be the source of a product, such as an antibody, that is associated with one or more genes on the foreign chromosome(s) or fragment(s).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.