Patent · US Expired

Adenovirus E1B-55K single amino acid mutants and methods of use

US6635244B2 · kind B2 · utility

4Cited by

1References

7Claims

0Family size

Assignee

Onyx Pharmaceuticals, Inc. · US

Inventors

Yuqiao Shen · Richmond, US
Julie Nye · Berkeley, US
Terry Hermiston · Corte Madera, US

Key dates

Filing date	Jul 30, 2001
Grant date	Oct 21, 2003
Priority date	—
Expiry date	Jul 30, 2021

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2710/10343
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Adenoviral mutants are described that have single amino acid mutations in the E1B-55K protein which mutations effect the p53 binding/inactivation and the late functions of the E1B-55K protein in a manner that enhances the efficacy of such viruses for treating cancer when compared to adenoviral mutants that have the E1B-55K region deleted.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.