Patent · US Expired

Particles of HCV envelope proteins: use for vaccination

US6635257B1 · kind B1 · utility

10Cited by

2References

28Claims

0Family size

Assignee

Innogenetics N.V. · BE

Inventors

Erik Depla · Laarne, BE
Geert Maertens · Brugge, BE
Alfons Bosman · Opwijk, BE
Frans Van Wijnendaele · Ottenburg, BE

Key dates

Filing date	Jul 23, 1999
Grant date	Oct 21, 2003
Priority date	—
Expiry date	Jul 23, 2019

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S530/826
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention is based on the finding that the envelope proteins of HCV induce a beneficial immune response in chronically HCV-infected chimpanzees. The immunization can preferentially be carried out using HCV envelope proteins in the form of particles which are produced in a detergent-assisted manner. The envelope proteins when presented as such to chronic HCV carriers are highly immunogenic and stimulate both the cellular and humoral immune response.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.