Cryopreservation system with controlled dendritic freezing front velocity
US6635414B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | May 22, 2001 |
| Grant date | Oct 21, 2003 |
| Priority date | — |
| Expiry date | May 22, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2001/2255
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A biopharmaceutical material cryopreservation system is provided that includes a flexible sterile container comprising a biocompatible polymeric material. The flexible sterile container contains biopharmaceuticals materials for freezing and cryopreservation. A freezing system is thermally coupled to the biopharmaceutical materials via the flexible sterile container. The freezing system comprises a temperature sensor that monitors a temperature of the biopharmaceutical materials. Also, the freezing system comprises a feedback loop constructed to control a dendritic freezing front velocity, within the biopharmaceutical materials, in a range from approximately 5 millimeters per hour to approximately 250 millimeters per hour based on feedback information from the temperature sensor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.