Heterodimeric nuclear receptors proteins, genes encoding same, and usage thereof
US6635429B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 23, 1994 |
| Grant date | Oct 21, 2003 |
| Priority date | — |
| Expiry date | Mar 23, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/80
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is based in part on the novel observation that two different types of nuclear receptors, retinoic acid receptors (RAR) and thyroid receptors (TR) dimerize with a RX receptor (RXR) to form a heterodimer which is capable of binding to retinoic acid response elements (RARE) or thyroid receptor response elements (TRE) at physiological conditions. In addition, the present invention discloses that RXR homodimers are capable of binding to RARE's. Based on this observation, the present invention provides novel dimeric proteins, methods of identifying agents capable of binding the dimers of the present invention, methods of identifying DNA sequences capable of being bound by the dimers and methods to identify RA metabolic enzymes and proteins which are required for the activation function of nuclear receptors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.