Peptide potentiation of acid-sensory ion channel in pain
US6635432B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 25, 2000 |
| Grant date | Oct 21, 2003 |
| Priority date | — |
| Expiry date | Apr 25, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/1016
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An assay for determining agonists, antagonists, or modulators for acid-sensing ion channels. The assay is especially useful for screening analgesics. The screening assay can be provided in a kit form. The assay comprises administering the composition to be screened to cells expressing acid-gated channels and then determining whether the composition inhibits, enhances, or has no effect on the channels when acid is introduced. The determination can be performed by analyzing whether a current is sustained by the cells in the presence of the composition and the acid. This current can be compared to that sustained by the FMRFamide and related peptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.