Polypeptides and polynucleotides from coagulase-negative staphylococci

US6635473B1 · kind B1 · utility

Assignees

• THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN · IE
• THE TEXAS A&M UNIVERSITY SYSTEM · US

Inventors

• Timothy J. Foster · Dublin, IE
• Kirk McCrea · Houston, US
• Magnus Hook · Houston, US
• Stacy Davis · Houston, US
• Deirdre Ni Eidhin · Dublin, IE
• Orla Hartford · Duleek, IE

Key dates

• Filing date: Aug 31, 1999
• Grant date: Oct 21, 2003
• Expiry date: Aug 31, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/505
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Isolated proteins, designated SdrF, SdrG and SdrH, and their corresponding amino acid and nucleic acid sequences are provided which are useful in the prevention and treatment of infection caused by coagulase-negative staphylococcal bacteria such as S. epidermidis. The SdrF, SdrG and SdrH proteins are cell-wall associated proteins that specifically bind host proteins and which each have a highly conserved motif of which the consensus sequence is TYTFTDYVD (SEQ ID NO:16). The proteins, antigenic portions thereof and anti-SdrF, SdrG and SdrH antibodies are also useful for the identification and diagnosis of coagulase-negative staphylococcal infections. In particular, the proteins are advantageous because they may be used as vaccine components or antibodies thereof, and they may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of coagulase-negative staphylococci to wounds or biomaterials.