Piperazinedione compounds

US6635649B2 · kind B2 · utility

Inventors

• Che-Ming Teng · Taipei, TW
• Hui Wang · Taipei, TW
• Eric I. C. Li · Tainan, TW
• On Lee · Taipei, TW
• Jih-Hwa Guh · Taipei, TW
• Huei-Ting Chen · Taipei, TW
• Ya-Bing Fan · Taipei, TW
• Ya-Lan Chen · Danei, TW

Key dates

• Filing date: May 8, 2001
• Grant date: Oct 21, 2003
• Expiry date: May 8, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Piperazinedione compounds of the formula: Each of and <CUSTOM-CHARACTER FILE="US06635649-20031021-P00900.TIF" ALT="custom character" HE="20" WI="20" ID="CUSTOM-CHARACTER-00001"/> and <CUSTOM-CHARACTER FILE="US06635649-20031021-P00901.TIF" ALT="custom character" HE="20" WI="20" ID="CUSTOM-CHARACTER-00002"/> independently, is a single bond or a double bond; A is H or CH(RaRb) when <CUSTOM-CHARACTER FILE="US06635649-20031021-P00900.TIF" ALT="custom character" HE="20" WI="20" ID="CUSTOM-CHARACTER-00003"/> is a single bond, or C(RaRb) when is a double bond; Z is R3O&#8212;(Ar)&#8212;B, in which B is CH(Rc) when <CUSTOM-CHARACTER FILE="US06635649-20031021-P00901.TIF" ALT="custom character" HE="20" WI="20" ID="CUSTOM-CHARACTER-00004"/> is a single bond, or C(Rc) when <CUSTOM-CHARACTER FILE="US06635649-20031021-P00901.TIF" ALT="custom character" HE="20" WI="20" ID="CUSTOM-CHARACTER-00005"/> is a double bond; Ar is heteroaryl; and R3 is H, alkyl, aryl, heteroaryl, C(O)Rd, C(O)ORd, C(O)NRdRe, or SO2Rd; each of R1 and R2, independently, is H, C(O)Rd, C(O)ORd, C(O)NRdRe, or SO2Rd; and each of Ra, Rb, Rc, Rd, and Re, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl. Optiona…