Therapeutic uses of di-aryl acid derivatives

US6635655B1 · kind B1 · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Zaid Jayyosi · Flemington, US
• Gerard McGeehan · Chester Springs, US
• Michael Kelley · Arlington, US
• Richard F. Labaudiniere · Sherborn, US
• Litao Zhang · Nazareth, US
• Robert D. Groneberg · Boulder, US
• Daniel McGarry · King of Prussia, US
• Thomas J. Caulfield · Lawrenceville, US
• Anne Minnich · Flemington, US
• Mark Bobko · Exton, US

Key dates

• Filing date: Sep 14, 2000
• Grant date: Oct 21, 2003
• Expiry date: Sep 14, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as PPAR ligand receptor binders. The PPAR ligand receptor binders of this invention are useful as agonists or antagonists of the PPAR receptor.