Imidazoline receptor binding compounds

US6635668B1 · kind B1 · utility

Assignee

• The University of North Carolina at Chapel Hill · US

Inventors

• Richard R. Tidwell · Pittsboro, US
• James E. Hall · Chapel Hill, US
• Dorothy H. Wood · Hillsborough, US

Key dates

• Filing date: Jul 22, 1998
• Grant date: Oct 21, 2003
• Expiry date: Jul 22, 2018

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pentamidine and analogs thereof have activity as imidazoline receptor binding compounds. A method of binding the imidazoline receptor, comprises contacting a bis-benzene to said imidazoline receptor in an amount effective to bind to said receptor, wherein said bis-benzene contains at least one amidine group (e.g., one or two). The contacting step may be carried out in vivo or in vitro. Contacting may be carried out with individual active compounds or with libraries of active compounds.