Cell-culture and polymer constructs
US6637437B1 · kind B1 · utility
65Cited by
7References
4Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Nov 14, 2000 |
| Grant date | Oct 28, 2003 |
| Priority date | — |
| Expiry date | Nov 14, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/72
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is directed to the culture of cells, and particularly chondrocytes for purpose of tissue replacement. The cells are cultured on polymer constructs. Integren expression is used as a measure of chondrocyte viability. Chondrocytes are obtained from the knee, nose and ankle cartilage. Mechanical strain is used to propagate chondrocytes, chitosan and arabinogalactanchitosan are used as scaffolds. Progenitor, pluripotential, stem and mesenchymal cells are operative in this invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.