Stabilized preparation for use in metered dose inhalers
US6638495B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 21, 2001 |
| Grant date | Oct 28, 2003 |
| Priority date | — |
| Expiry date | May 28, 2021 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/926
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a hydrofluoroalkane propellant. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as, by settling or flocculation. In particularly preferred embodiments, the stabilized dispersions may be administered to the lung of a patient using a metered dose inhaler.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.