Compounds and methods for modulating desmosomal cadherin-mediated functions
US6638911B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 27, 2000 |
| Grant date | Oct 28, 2003 |
| Priority date | — |
| Expiry date | Mar 27, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/805
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Modulating agents for inhibiting or enhancing desmosomal cadherin mediated cell adhesion are provided. The modulating agents comprise one or more of: (a) a peptide sequence that is at least 50% identical to a desmosomal cadherin CAR sequence; (b) a non-peptide mimetic of a desmosomal cadherin CAR sequence; (c) a substance, such as an antibody or antigen-binding fragment thereof, that specifically binds a desmosomal cadherin CAR sequence; and/or (d) a polynucleotide encoding a polypeptide that comprises a desmosomal cadherin CAR sequence or analogue thereof. Methods for using such modulating agents for modulating desmosomal cadherin-mediated cell adhesion in a variety of contexts are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.