Cycloheptene compounds

US6638962B2 · kind B2 · utility

Assignee

• LES LABORATOIRES SERVIER · FR

Inventors

• Patrick Casara · Carrières-sous-Poissy, FR
• Thierry Le Diguarher · Saint-Jean-de-Braye, FR
• Gilbert Dorey · Chaville, FR
• John Hickman · Paris, FR
• Alain Pierre · Marly-le-Roi, FR
• Gordon Tucker · Paris, FR
• Nicolas Guilbaud · Paris, FR

Key dates

• Filing date: Jan 16, 2002
• Grant date: Oct 28, 2003
• Expiry date: Jan 16, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compound of formula (I): wherein:X represents a bond or alkylene, CO, S(O)n, —S(O)n—A1—, —CO—A1—, —A—S(O)n—A′1— or —A1—CO—A′1—,Y represents aryl, heteroaryl, cycloalkyl or heterocycloalkyl, each unsubstituted or substituted,R1, R2, R3 and R4 each independently of the others represent hydrogen or aryl, heteroaryl, cycloalkyl or heterocycloalkyl, each unsubstituted or substituted,or R1, R2, R3 and R4, taken in pairs, together form a bond, or form a fused benzene ring or a fused aromatic or partially unsaturated heterocycle,T represents —CH(R5)—, —N(R5)— or —N(R5)CO—,V represents hydrogen or unsubstituted or substituted aryl or heteroaryl,A2 represents [C(R6)(R′6)]p,R7 and R8 are as defined in the description,their isomers and addition salts thereof with a pharmaceutically acceptable acid or base and medicinal products containing the same are useful as farnesyl transferase inhibitors.