Substituted indolinones, preparation thereof and their use as pharmaceutical compositions

US6638965B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Rainer Walter · Biberach, DE
• Armin Heckel · Biberach an der Riß, DE
• Gerald Juergen Roth · Biberach, DE
• Joerg Kley · Mittelbiberach, DE
• Gisela Schnapp · Biberach an der Riß, DE
• Martin Lenter · Ulm, DE
• Jacobus Van Meel · Biberach, DE
• Walter Spevak · Stockerau, AT
• Ulrike Weyer-Czernilofsky · Baden, AT

Key dates

• Filing date: Nov 1, 2001
• Grant date: Oct 28, 2003
• Expiry date: Nov 1, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Indolinones of general formula I which are inhibitors of cell proliferation, particularly of tumour cells, and inhibitors of protein kinases. The following compounds are exemplary:(Z)-3-{1-[4-(N-(2-aminoethyl)-N-methylsulphonyl-amino)-phenylamino]-1-phenyl-methylidene}-5-phenylsulphonylamino-2-indolinone,(Z)-3-{1-[4-(N-(2-dimethylaminoethyl)-N-phenylsulphonyl-amino)-phenylamino]-1-phenyl-methylidene}-5-phenylsulphonylamino-2-indolinone, and(Z)-3-{1-[4-(4-methylpiperazinomethyl)-phenylamino]-1-phenyl-methylidene}-5-phenylsulphonylamino-2-indolinone.