NRIF3, novel co-activator for nuclear hormone receptors
US6639064B1 · kind B1 · utility
4Cited by
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9Claims
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Key dates
| Filing date | Sep 15, 2000 |
| Grant date | Oct 28, 2003 |
| Priority date | — |
| Expiry date | Sep 27, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/4705
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Nucleic acids encoding NRIF3 are described. Polypeptides having amino acid sequences of NRIF3 proteins are also provided. A method is also provided for isolating and cloning NRIF3 cDNA. NRIF3 is useful in development/implementation of high throughput screens to identify novel thyroid hormone receptor (TR) and retinoid X receptor (RXR) agonists and antagonists. Methods are also provided for identifying compounds that directly interfere with the interaction of NRIF3 and TR or RXR. Finally, therapies based on modulation of NRIF3 activity are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.