Method for separation of isomers and different conformations of ions in gaseous phase
US6639212B1 · kind B1 · utility
72Cited by
13References
57Claims
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Assignee
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Key dates
| Filing date | Apr 12, 2001 |
| Grant date | Oct 28, 2003 |
| Priority date | — |
| Expiry date | Apr 12, 2021 |
Classification
- Technology area (CPC H)Electricity
- CPC primaryH01J49/044
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present invention relates to a method of separating ions having the same mass to charge ratio but different ion mobility characteristics, based on the ion focussing principles of high field asymmetric waveform ion mobility spectrometry. Isomers including gas-phase molecular anions of the amino acids leucine and isoleucine are separable by the method of the present invention. Identification of different conformers of ions at the same charge state, including conformers present at certain charge states of the protein bovine ubiquitin, is also possible using the method of the present invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.