Library design in combinatorial chemistry by Monte Carlo methods
US6640191B1 · kind B1 · utility
8Cited by
1References
17Claims
0Family size
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Key dates
| Filing date | Dec 30, 1999 |
| Grant date | Oct 28, 2003 |
| Priority date | — |
| Expiry date | Dec 30, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N31/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods for generating multiple rounds of combinatorial libraries, which use Monte Carlo methods to search the multi-dimensional composition and non-composition space of variables in combinatorial chemistry; the combinatorial libraries generated and screened by such Monte Carlo methods; and an apparatus for generating and screening such libraries robotically. The process involves preparing a first set of samples, then changing the composition and non-composition variables of the samples using Monte Carlo sampling methods, and accepting proposed new samples according to a detailed balance acceptance criterion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.